Humans

Effect on Intermittent Hypoxia on Plasma Exosomal Micro RNA Signature and Endothelial Function in Healthy Adults
STUDY OBJECTIVE: Intermittent hypoxia (IH) is associated with increased risk of cardiovascular disease. Exosomes are secreted by most …
Abdelnaby Khalyfa, Chunling Zhang, Ahamed A. Khalyfa, Glen E. Foster, Andrew E. Beaudin, Jorge Andrade, Patrick J. Hanly, Marc J. Poulin, David Gozal
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Measuring the human ventilatory and cerebral blood flow response to CO$_textrm2$: a technical consideration for the end-tidal-to-arterial gas gradient
Michael M Tymko, Ryan L Hoiland, Tomas Kuca, Lindsey M Boulet, Joshua C Tremblay, Bryenna K Pinske, Alexandra M Williams, Glen E Foster
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Quantifying the shape of the maximal expiratory flow-volume curve in mild COPD
Maximal expiratory flow-volume (MEFV) curve evaluation using absolute and percent predicted values of flow and volume are used to …
Paolo B. Dominelli, Glen E. Foster, Jordan A. Guenette, Hans C. Haverkamp, Neil D. Eves, Giulio S. Dominelli, William R. Henderson, Denis E. O'Donnell, A. William Sheel
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DYSANAPSIS AND THE RESISTIVE WORK OF BREATHING DURING EXERCISE IN HEALTHY MEN AND WOMEN
Paolo B Dominelli, Yannick Molgat-Seon, Derek Bingham, Philippa M Swartz, Jeremy D Road, Glen Edward Foster, Andrew William Sheel
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Chemoreceptor Responsiveness at Sea Level Does Not Predict the Pulmonary Pressure Response to High Altitude.
BACKGROUND:The hypoxic ventilatory response (HVR) at sea level (SL) is moderately predictive of the change in pulmonary artery systolic …
Ryan L Hoiland, Glen E Foster, Joseph Donnelly, Mike Stembridge, Chris K Willie, Kurt J Smith, Nia C Lewis, Samuel J E Lucas, Jim D Cotter, David J Yeoman, Kate N Thomas, Trevor A Day, Mike M Tymko, Keith R Burgess, Philip N Ainslie
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End tidal-to-arterial CO$_textrm2$ and O$_textrm2$ gas gradients at low- and high-altitude during dynamic end-tidal forcing.
We sought to characterize and quantify the performance of a portable dynamic end-tidal forcing (DEF) system in controlling the partial …
Michael M Tymko, Philip N Ainslie, David B MacLeod, Chris K Willie, Glen E Foster
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The contribution of arterial blood gases in cerebral blood flow regulation and fuel utilization in man at high altitude.
The effects of partial acclimatization to high altitude (HA; 5,050 m) on cerebral metabolism and cerebrovascular function have not been …
Christopher K Willie, David B MacLeod, Kurt J Smith, Nia C Lewis, Glen E Foster, Keita Ikeda, Ryan L Hoiland, Philip N Ainslie
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Oxygen cost of exercise hyperpnoea is greater in women compared with men
KEY POINTS: The oxygen cost of breathing represents a significant fraction of total oxygen uptake during intense exercise. At a given …
Paolo B. Dominelli, Jacqueline N. Render, Yannick Molgat-Seon, Glen E. Foster, Lee M. Romer, A. William Sheel
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Hypoxia, not pulmonary vascular pressure, induces blood flow through intrapulmonary arteriovenous anastomoses.
KEY POINTS:Blood flow through intrapulmonary arteriovenous anastomoses (IPAVA) is increased by acute hypoxia during rest by unknown …
Joshua C Tremblay, Andrew T Lovering, Philip N Ainslie, Mike Stembridge, Keith R Burgess, Akke Bakker, Joseph Donnelly, Samuel J E Lucas, Nia C S Lewis, Paolo B Dominelli, William R Henderson, Giulio S Dominelli, A William Sheel, Glen E Foster
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Impact of hypocapnia and cerebral perfusion on orthostatic tolerance.
We examined two novel hypotheses: (1) that orthostatic tolerance (OT) would be prolonged when hyperventilatory-induced hypocapnia (and …
Nia C S Lewis, Anthony R Bain, David B MacLeod, Kevin W Wildfong, Kurt J Smith, Christopher K Willie, Marit L Sanders, Tianne Numan, Shawnda A Morrison, Glen E Foster, Julian M Stewart, Philip N Ainslie
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