Respiration

Respiration
The sensitivity of the respiratory control system can dictate human success in the high altitude environment and can contribute to disease. Our research focuses on how respiratory chemoreception impacts breathing stability at altitude and how simulated sleep apnea influences respiratory control. We are currently developing a novel approach to better understand the redistribution of blood flow to the muscles of respiration during increases in respiratory work.
Respiration
Influence of methazolamide on the human control of breathing: A comparison to acetazolamide
New Findings What is the central question of this study? Acetazolamide and methazolamide both reduce hypoxic pulmonary vasoconstriction …
Luc J. Teppema, Lindsey M. Boulet, Heather K. Hackett, Paolo B. Dominelli, William S. Cheyne, Giulio S. Dominelli, Erik R. Swenson, Glen E. Foster
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Influence of methazolamide on the human control of breathing: A comparison to acetazolamide
The effect of consistent practice of yogic breathing exercises on the human cardiorespiratory system
Joshua A A McKay, Cara L McCulloch, Jordan S Querido, Glen E Foster, Michael S Koehle, A William Sheel
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Role of CO2 in the cerebral hyperemic response to incremental normoxic and hyperoxic exercise.
Cerebral blood flow (CBF) is temporally related to exercise-induced changes in partial pressure of end-tidal carbon dioxide (PetCO2 ); …
Kurt J Smith, K W Wildfong, R L Hoiland, M Harper, N C Lewis, A Pool, S L Smith, T Kuca, G E Foster, P N Ainslie
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Gas density alters expiratory time constants before and after experimental lung injury
William R Henderson, Yannick Molgat-Seon, Paolo B Dominelli, Penelope M A Brasher, Donald E G Griesdale, Glen E Foster, Alexandra Yacyshyn, Najib T Ayas, A William Sheel
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Oxygen cost of exercise hyperpnoea is greater in women compared with men
KEY POINTS: The oxygen cost of breathing represents a significant fraction of total oxygen uptake during intense exercise. At a given …
Paolo B. Dominelli, Jacqueline N. Render, Yannick Molgat-Seon, Glen E. Foster, Lee M. Romer, A. William Sheel
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Precise mimicking of exercise hyperpnea to investigate the oxygen cost of breathing
The oxygen cost of exercise hyperpnea (V˙(O2 RM)) has been quantified using a variety of techniques with inconsistent findings. …
P. B. Dominelli, J. N. Render, Y. Molgat-Seon, G. E. Foster, A. W. Sheel
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Effects of intermittent hypoxia on erythropoietin, soluble erythropoietin receptor and ventilation in humans
In this study, we demonstrated for the first time in humans (n = 9) that sEPOR is downregulated upon daytime exposure to 4 days of …
J V Brugniaux, V Pialoux, G E Foster, C T C Duggan, M Eliasziw, P J Hanly, M J Poulin
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Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia
We determined the ventilatory, cardiovascular and cerebral tissue oxygen response to two protocols of normobaric, isocapnic, …
Glen E. Foster, Donald C. McKenzie, William K. Milsom, A. William Sheel
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Repeated measurement of hypoxic ventilatory response as an intermittent hypoxic stimulus.
Measurement of hypoxic ventilatory response (HVR) involves an exposure to hypoxia which, if repeated over several days might act as an …
Michael S Koehle, Glen E Foster, Donald C McKenzie, A William Sheel
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